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Published on AidPage by IDILOGIC on Jun 24, 2005
Administered by:

Department of Health and Human Services, National Institutes of Health, National Institutes of Health
(see all US Federal Agencies)

Explore all postings for this grant program:
  • Original Grant - Dec 15, 2003
Applications Due:

Multiple Receipt Dates - See Link to Full Announcement for details.

total funding: Not Available
max award: none
min award: none
cost sharing, matching: No
number of awards: Not Available
type of funding: Grant

The purpose of this PA is to develop novel technologies for capturing,
enriching, and preserving exfoliated abnormal cells and macromolecules in
body fluids or effusions and to develop methods for concentrating the
enriched cells for biomarker studies. In the context of this PA, we have
extended the definition of exfoliation to include not only the cellular
materials, but also subcellular materials, such as DNA and proteins. In body
fluids, such as sputum, the number of exfoliated tumor cells is often small
compared to the number of non-neoplastic cells. Therefore, the detection of
exfoliated abnormal cells by routine cytopathology is often limited because
few atypical cells may be present in the specimen. There may be difficulty in
separating dysplastic cells from non-specific reactive changes and
degenerating cells or variation in diagnostic criteria. Furthermore,
exfoliated cells are frequently contaminated with normal cells, bacteria, and
other cellular debris, which makes molecular analysis difficult without
physical separation of the neoplastic cells. Thus, the development of
enrichment methods becomes prerequisite for the routine detection of small
numbers of exfoliated cells and small amounts of subcellular materials in
biological fluids for molecular analysis. Similarly, subcellular materials
are in amounts that may not be detectable by available technologies and
therefore the enrichment of such materials is of paramount importance.
Enrichment will allow exfoliated cells and subcellular molecules, for example
from urine, to be used for genomic, proteomic, and epigenomic analyses that
may lead to improvements in the detection of bladder cancer through
measurements of alterations in expressed genes, peptide profiles, and
epigenetic markers.

Who can apply:

Anyone/General Public
City Or Township Governments
County Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Minority Group
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Profit Organization
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)

Eligible functional categories:
Funding Sources:

Cancer Cause and Prevention Research
Cancer Detection and Diagnosis Research

More Information:


If you have problems accessing the full announcement, please contact: NIH OER Webmaster

Address Info:

Office of Extramural Programs
6705 Rockledge Drive
Bethesda, MD 20892-7963

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